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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN1
All Species:
24.55
Human Site:
T274
Identified Species:
41.54
UniProt:
P49768
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49768
NP_000012.1
467
52668
T274
P
L
R
M
L
V
E
T
A
Q
E
R
N
E
T
Chimpanzee
Pan troglodytes
XP_001149972
443
50485
P264
D
L
V
A
V
L
C
P
K
G
P
L
R
M
L
Rhesus Macaque
Macaca mulatta
XP_001088524
384
43068
Y205
T
L
F
P
A
L
I
Y
S
S
T
M
V
W
L
Dog
Lupus familis
XP_547503
717
78133
H489
A
V
G
M
V
C
I
H
W
K
G
P
L
V
L
Cat
Felis silvestris
Mouse
Mus musculus
P49769
467
52621
T274
P
L
R
M
L
V
E
T
A
Q
E
R
N
E
T
Rat
Rattus norvegicus
P97887
468
52771
T274
P
L
R
M
L
V
E
T
A
Q
E
R
N
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
L276
P
K
G
P
L
R
M
L
V
E
T
A
Q
E
R
Chicken
Gallus gallus
Q4JIM4
468
52812
T275
P
L
R
M
L
V
E
T
A
Q
E
R
N
E
T
Frog
Xenopus laevis
O12976
433
48282
Y254
T
L
F
P
A
L
I
Y
S
S
T
M
I
W
L
Zebra Danio
Brachydanio rerio
Q9W6T7
456
50963
I271
A
Q
E
R
N
E
A
I
F
P
A
L
I
Y
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
T296
P
L
R
I
L
V
E
T
A
Q
E
R
N
E
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
Y265
S
S
G
V
I
Y
P
Y
V
L
V
T
A
V
E
Sea Urchin
Strong. purpuratus
XP_001178715
518
58077
T307
P
L
R
M
L
V
E
T
A
Q
E
R
D
E
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64668
453
49290
N271
V
N
Q
L
G
R
E
N
S
H
N
M
D
Y
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
82.2
46.2
N.A.
92.7
92.5
N.A.
62.3
82.2
77.3
70.8
N.A.
47.6
N.A.
49
55.6
Protein Similarity:
100
90.7
82.2
52
N.A.
96.5
96.5
N.A.
73.6
89.7
83
79
N.A.
63.4
N.A.
64
68.1
P-Site Identity:
100
6.6
6.6
6.6
N.A.
100
100
N.A.
20
100
6.6
0
N.A.
86.6
N.A.
0
86.6
P-Site Similarity:
100
20
20
26.6
N.A.
100
100
N.A.
26.6
100
20
6.6
N.A.
93.3
N.A.
13.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
8
15
0
8
0
43
0
8
8
8
0
0
% A
% Cys:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% D
% Glu:
0
0
8
0
0
8
50
0
0
8
43
0
0
50
8
% E
% Phe:
0
0
15
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
22
0
8
0
0
0
0
8
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
8
8
0
22
8
0
0
0
0
15
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
8
8
0
0
0
0
0
% K
% Leu:
0
65
0
8
50
22
0
8
0
8
0
15
8
0
29
% L
% Met:
0
0
0
43
0
0
8
0
0
0
0
22
0
8
0
% M
% Asn:
0
8
0
0
8
0
0
8
0
0
8
0
36
0
8
% N
% Pro:
50
0
0
22
0
0
8
8
0
8
8
8
0
0
0
% P
% Gln:
0
8
8
0
0
0
0
0
0
43
0
0
8
0
15
% Q
% Arg:
0
0
43
8
0
15
0
0
0
0
0
43
8
0
8
% R
% Ser:
8
8
0
0
0
0
0
0
22
15
0
0
0
0
8
% S
% Thr:
15
0
0
0
0
0
0
43
0
0
22
8
0
0
29
% T
% Val:
8
8
8
8
15
43
0
0
15
0
8
0
8
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
15
0
% W
% Tyr:
0
0
0
0
0
8
0
22
0
0
0
0
0
15
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _